Schwannoma of the uterine cervix: a rare case report

Schwannomas are neurogenic tumors, which are among the most varied tumors with respect to morphology, clinical associations, and presentations; they occur in a wide variety of sites. The uterine cervix is a rare site of occurrence and only 15 cases of schwannomas of the uterine cervix, including 5 benign and 10 malignant cases, have been reported to date. Thus, schwannomas of the uterine cervix may pose diagnostic difficulty. Here, we report a case of benign schwannoma of the uterine cervix in a 37-year-old female, who presented with vaginal spotting.

Expression of cyclin Dl and PI 6 in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma [ESCC] is one of the lethal cancers with a high incidence rate iri Asia. Many genes including cyclin Dl and pi6 play important role in its carcinogenesis. We aimed to analyze the expressions of cyclin Dl and pi6 with the various clinicopathological characteristics of ESCC. We examined 30 biopsy samples of ESCC for cyclin Dl and p!6 protein expressions using immunohistochemistry. Immunointensity was classified as no immunostaining [-], weakly immunostaining [+], weak immunostaining [H-] and strongly positive immunostaining [+++]. Out of the 30 cases, positive expression of cyclin Dl was detected in 26 cases [86.7%]. The percentage of tumors with invasion to the adventitia [88.2%], lymph node metastasis [87.5%], and tumors which were poorly differentiated [92.9%] were higher in cyclin Dl positive tumors than in the cyclin Dl negative tumors. However no significant association was found between cyclin Dl expression and the different clinicopathological parameters.There were 22 cases of ESCC [73.3%] which showed negativity for pi6. The percentage of tumors with invasion to the adventitia [82.4%] and poorly differentiated tumors [92.9%] were higher in the pi6 negative tumors than in the pi6 positive tumors. There was significant association between the histological grade and p16 expression [p=0.012]. However, there were no significant association with regard to site, size and lymph node status of the tumors and p 16 expression

Mucinous adenocarcinoma of the renal pelvis with adenocarcinoma in situ of the ureter

Primary epithelial tumor of the renal pelvis is rare, and adenocarcinomas account for less than 1% of malignancies arising from the epithelium of the renal pelvis. We describe in this study a case of a 56- year old male patient who presented with an abdominal mass and dull aching pain for one year. A diagnosis of hydronephrosis of the right kidney was made based on imaging studies. Grossly, the entire kidney was converted into a cystic mass measuring 16 x 12 x 10 cm and filled with gelatinous material along with staghorn calculi in the pelvis measuring 7 x 4 x 3 cm. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made